Structural identification of putative USPs in Catharanthus roseus
نویسندگان
چکیده
منابع مشابه
5-Methyltryptophan resistant cells of Catharanthus roseus.
Several cell lines resistant to 5-methyltryptophan were selected from wild type cells of different Catharanthus roseus suspension cultures. The resistant cells had up to 30 times the normal levels of free tryptophan. Despite the increased pool size of tryptophan anthranilate synthetase activity of resistant cells was as sensitive to inhibition by L-tryptophan as wild type cells. The overproduct...
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The (seco)iridoids and their derivatives, the monoterpenoid indole alkaloids (MIAs), form two large families of plant-derived bioactive compounds with a wide spectrum of high-value pharmacological and insect-repellent activities. Vinblastine and vincristine, MIAs used as anticancer drugs, are produced by Catharanthus roseus in extremely low levels, leading to high market prices and poor availab...
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The low yield and high market price of the pharmaceutically important alkaloids of Catharanthus roseus (L.) G. Don viz. vincristine, vinblastine and ajmalicine have created interest in improved alternative routes for their production such as using cell and tissue culture. The callus developed on Murashige and Skoog (MS) media supplemented with different concentrations of auxins and cytokinins w...
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Catharanthus roseus or vinca produces over 130 TIAs with pharmaceutical value. Two of them, namely vinblastine (VB) and vincristine (VC), are species-specific and extensively used in anticancer chemotherapeutics. To detect C. roseus genotypes abundant in desired TIAs, contrasting genotypes should be analyzed via marker-assisted selection (MAS) to avoid analytical quantitation. A trustable morph...
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No study has been performed on identifying microRNAs (miRNAs) and their targets in the medicinal plant, Catharanthus roseus. In the present study, using the comparative genomics approach, we have predicted two potential C. roseus miRNAs. Furthermore, twelve potential mRNA targets were identified in C. roseus genome based on the characteristics that miRNAs exhibit perfect or nearly perfect compl...
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ژورنال
عنوان ژورنال: Comptes Rendus Biologies
سال: 2015
ISSN: 1631-0691
DOI: 10.1016/j.crvi.2015.07.008